TrumpRx: drug list, prices, and how the new discount site works

TrumpRx went live this week as a federal prescription-discount portal built around “most-favored-nation” pricing claims and downloadable coupons for cash-pay consumers. The launch put immediate attention on two practical questions: what’s actually on the TrumpRx list of drugs right now, and whether the prices beat what patients can already find through existing discount-coupon options or insurance.

At launch, the site shows 43 medications, heavily weighted toward brand-name products, with the biggest headline cuts centered on popular GLP-1 weight-loss therapies and several fertility drugs. The savings can be large versus list price, but the out-of-pocket totals can still be substantial—especially for people who rely on insurance deductibles and pharmacy benefits.

What TrumpRx is, in plain terms

TrumpRx functions as a shopping-and-coupon hub, not a single government-run pharmacy. Patients search a medication, then use a coupon or follow a purchase path tied to the manufacturer or participating pharmacies. The pricing is presented as a “lowest cash price,” paired with an “original price” reference.

This structure means the program’s impact depends on whether:

• your medication appears on the list,

• your local pharmacy accepts the coupon processing route, and

• the quoted cash price beats your insurance copay (or another discount coupon).

TrumpRx list of drugs: what’s included at launch

The current TrumpRx medication list spans several categories, including:

• Weight-loss / metabolic: Wegovy, Ozempic, Zepbound

• Fertility: Gonal-F, Cetrotide, Ovidrel

• Respiratory: Bevespi, Airsupra

• Other chronic therapies: selected hormone therapies and specialty drugs

The list is not broad enough to cover “most prescriptions,” and it leans toward a mix of high-profile blockbuster brands and select specialty medications. Many common generics are not the centerpiece of the offering, which shapes who is most likely to benefit.

TrumpRx prices: a snapshot of featured deals

Here are examples shown on the site’s “browse” list (prices shown as listed, per the displayed product form):

These are eye-catching reductions from list price. The tradeoff is that “down from list” does not always equal “best available,” particularly when a cheaper generic exists or when an insured copay is lower than the discounted cash price.

Where the program may help — and where it may not

Most likely to benefit

• Uninsured or underinsured patients paying full retail prices today.

• People needing fertility medications that are often poorly covered by insurance.

• Some patients paying out of pocket for GLP-1 drugs when insurance coverage is limited or excluded.

Less likely to benefit

• Patients whose insurance already delivers a low copay for the same drug.

• People for whom paying cash would mean the purchase doesn’t count toward a deductible or out-of-pocket maximum.

• Patients whose medication has a widely available low-cost generic, where the lowest-cost choice may not be the branded product.

A key consumer risk is “anchoring”: a large percentage discount can feel like a great deal even when the final price is still higher than other options.

How to use TrumpRx safely as a shopper

If you’re checking the TrumpRx website for a specific drug, a simple approach can prevent overpaying:

1. Check your insurance copay first (if you’re insured).

2. Compare the TrumpRx cash price with one other discount-coupon price at your preferred pharmacy.

3. Ask the pharmacist whether the coupon route is accepted and what the final out-the-door price is before filling.

4. If a generic exists, ask your prescriber whether it’s clinically appropriate for you.

5. Keep in mind that cash purchases may not apply to your plan’s deductible.

What to watch next

The biggest near-term variable is expansion: whether more manufacturers add drugs and whether the list grows beyond a launch set dominated by a small cluster of companies and a handful of headline therapies. Another open question is durability—how long the discounted prices remain available and how consistently pharmacies process the coupons at the displayed rates.

For now, TrumpRx is best understood as a new front door to certain discounted brand medications, not a universal solution for prescription affordability. For many patients, it will be one more price to compare—sometimes a winner, sometimes not.

Sources consulted: The White House, Reuters, Axios, Fast Company