U of A Study Explores Growth Hormones’ Impact on Dogs’ Cognitive Aging
Researchers at the University of Arizona College of Veterinary Medicine are launching a new project to probe aging in companion dogs. The team focuses on IGF-1, a growth hormone linked to body size and aging.
From observation to hypothesis
Investigators noticed a puzzling pattern in earlier surveys. Large breeds often die younger than small breeds, yet cognitive aging appears to follow a similar timeline across sizes.
That observation prompted a fresh question. Could circulating IGF-1 levels explain differences in cognitive aging among similarly sized dogs?
About the SIGNAL study
The Study of IGF‑1, Neurocognitive Aging and Longevity goes by the acronym SIGNAL. It will enroll 75 medium-sized dogs from the local community.
The project received support from the American Kennel Club Canine Health Foundation. Researchers plan a two-year protocol of blood tests and in-person cognitive assessments.
Study goals and methods
Investigators will measure hormone concentrations in blood. They will pair those values with performance on cognitive tasks collected over time.
The main aim is to determine whether dogs of similar size show different cognitive aging tied to IGF-1. The team hypothesizes higher IGF-1 may correlate with better task performance.
Scientific rationale
IGF-1 helps determine the broad range of dog body sizes. Prior work also links this hormone to lifespan and neural health in other species.
While IGF-1 can be associated with cancer risk, it may also support neuronal repair and growth. Those opposing effects make it an important target for study.
Team and collaboration
Lead investigator Evan MacLean directs the Arizona Canine Cognition Center. His personal interest includes his own aging dog, Sisu.
Co-investigators include Emily Bray, assistant professor of human-animal interaction, and Gene Alexander, professor of psychology. Additional collaborators hail from Arizona State University, Colorado State University and Tufts University.
Who can take part
The study seeks community participants with dogs aged 10 to 13 years. Eligible animals should weigh between 15 and 25 kilograms (33 to 55 pounds).
Owners may contact the Arizona Canine Cognition Center by email or enroll via the center’s online portal.
Broader implications
Researchers hope results will improve understanding of cognitive aging in pets and people. The team emphasizes that companion dogs offer genetic diversity and real-world living conditions.
This U of A work will examine growth hormones and their potential impact on dogs’ cognitive aging. Findings could inform human aging research and veterinary care strategies.
For more information or to inquire about participation, contact the Arizona Canine Cognition Center. Coverage of the study appears on Filmogaz.com.
