Memory of a Killer: Patrick Dempsey’s new Fox thriller, cast, episodes, and where to watch

Memory of a Killer is the new Patrick Dempsey show pulling him far from Grey’s Anatomy romance and into a tense, modern crime thriller. He plays a devoted family man with a secret second life as a professional killer—until early-onset Alzheimer’s begins to scramble the one thing his double life depends on: control.

For viewers who still think of Dempsey as “McDreamy,” the whiplash is the point. This time, the stakes aren’t will-they-won’t-they; they’re what happens when memory loss collides with a job where one forgotten detail can get someone killed.

What Memory of a Killer is about

Memory of a Killer centers on Angelo, a suburban father who’s been living two separate lives with strict rules and airtight routines. By day, he blends into ordinary work and family obligations; by night, he handles violent, high-risk jobs for people you don’t cross twice.

The twist is cruelly simple: Angelo’s diagnosis forces him into a race against his own mind. Familiar faces become uncertain, timing gets slippery, and the smallest lapse—misplaced keys, a forgotten passcode, a missed tail—can unravel years of careful compartmentalization. The show leans into that pressure, using Alzheimer’s not as a gimmick, but as a ticking clock that changes how every scene plays.

What to watch next: the early episodes set up a collision course between Angelo’s family life and the people who know what he really does, with his memory as the weak link neither side can predict.

Memory of a Killer cast: who’s in it with Patrick Dempsey

Dempsey is the anchor, but the series is built to feel like a web tightening around him—law enforcement, criminal contacts, and family members all pulling in different directions.

Key cast members include:

• Patrick Dempsey as Angelo (a family man hiding an assassin’s life)

• Michael Imperioli as Dutch

• Gina Torres as Linda Grant

• Odeya Rush as Maria

• Richard Harmon as Joe

• Daniel David Stewart as Jeff

• Peter Gadiot as Dave

• Michaela McManus as Nicky

The performances that tend to stand out early are the ones closest to Angelo’s fault lines: the people who can expose him, and the people he’s desperate to protect. That contrast—warmth at home, menace outside—gives the ensemble room to play even when the plot turns fast.

What to watch next: pay attention to which characters start noticing Angelo’s “small” mistakes first, because the show treats observation as a weapon.

Memory of a Killer episodes: how many, and the release schedule

Season 1 is planned as a 10-episode run, designed to move quickly rather than stretch into a 22-episode marathon. The series launched with a two-night premiere:

• Episode 1 (“Pilot”) aired Sunday, January 25, 2026

• Episode 2 (“Ferryman”) aired Monday, January 26, 2026

From there, the show shifts into a weekly rhythm. Current listings show new episodes continuing on Mondays, and early episode titles circulating include “Samurai” for the next installment. Titles and exact airdates beyond the near-term window can still change as schedules get adjusted, so it’s normal to see some episode slots listed without firm names yet.

If you’re tracking it like a checklist, the simplest way is to treat it as: two-night launch, then weekly Mondays until the 10 episodes complete.

What to watch next: the midseason stretch is where the series is expected to clarify whether it’s leaning more into a character-driven spiral (memory loss and identity) or a higher-velocity conspiracy thriller.

Memory of a Killer where to watch: Fox broadcast and streaming options

If you want to watch on Fox, the regular slot is:
US (ET): Mondays at 9:00 p.m.
Cairo: Tuesdays at 4:00 a.m. (timing can shift with daylight saving changes)

If you’d rather stream, new episodes are set up to land the next day on Hulu, which is the easiest way to keep up without staying up overnight in Cairo. You can also watch Fox through any live TV setup that carries your local Fox station, but availability depends on where you live and what your provider includes.

One quick note on searches: you’ll see people type “memories of a killer” (plural). That phrasing often points to the same conversation around this series, but it can also surface unrelated true-crime titles with similar names—so matching “Patrick Dempsey” and “Fox” in your search terms helps you land on the right one.

What to watch next: as the weekly run settles in, the biggest “where to watch” shift to monitor is whether any catch-up windows or episode availability rules change after the premiere week.