Greg Peterson Reveals Top MLB Bets for Saturday, April 4

Emerson Raymont

Published: April 4, 2026 3:33 PM ET

Greg Peterson Reveals Top MLB Bets for Saturday, April 4

Expert baseball handicapper Greg Peterson shares his top MLB bets for Saturday, April 4, 2026. Here’s a detailed breakdown of the key matchups and predictions.

St. Louis Cardinals vs. Detroit Tigers

The game kicks off at 1:10 PM Eastern. Both starting pitchers struggled during the previous season. St. Louis Cardinals’ Dustin May finished with a 4.96 ERA and allowed 1.4 home runs per nine innings. Meanwhile, Detroit Tigers’ Jack Flaherty had a 4.64 ERA and 1.3 home runs allowed.

Both bullpens have also had a difficult start to the season. The Cardinals rank 21st in bullpen ERA at 4.91, and the Tigers are slightly worse at 4.95.

Pick: Over 7.5 Runs (Greg’s Handicapped Total 8.3)

Los Angeles Dodgers vs. Washington Nationals

This matchup starts at 4:05 PM Eastern. The Dodgers scored 13 runs on Friday but averaged just 23 runs in their first six games. They face Nationals pitcher Jake Irvin, who posted a rough 5.70 ERA last season.

In contrast, Dodgers pitcher Tyler Glasnow had a solid 3.19 ERA and maintained a strong strikeout rate with only one home run allowed last year.

Pick: Under 9.5 Runs (Greg’s Handicapped Total 8.9)

Baltimore Orioles vs. Pittsburgh Pirates

The game features Pirates pitcher Carmen Mlodzinski, who had a mixed performance with a 3.55 ERA overall but struggled as a starter with a 4.99 ERA. The Orioles counter with Shane Baz, who approaches the season with optimism despite a previous 4.87 ERA.

Pick: Orioles Moneyline -115 (Greg’s Handicap Orioles -129)

San Diego Padres vs. Boston Red Sox

In this contest, the Padres’ Randy Vasquez faces Red Sox pitcher Connelly Early, who dazzled with a 2.19 ERA in a limited sample size. The Red Sox’s bullpen also ranked well, maintaining a 3.41 ERA last season.

Pick: Red Sox Moneyline -136 and Over 8 Runs (Greg’s Handicap Red Sox -165 and Total 9.1)

Tampa Bay Rays vs. Minnesota Twins

Starting at 7:10 PM Eastern, Tampa’s Steven Matz comes off a solid season with a 3.05 ERA. In contrast, Twins pitcher Mick Abel struggled with a 6.23 ERA. The Rays lineup has been effective, averaging five runs per game this season.

Pick: Rays Moneyline +105 and Over 7.5 Runs (Greg’s Handicap Rays -133 and Total 8.1)

Milwaukee Brewers vs. Kansas City Royals

The Brewers’ Brandon Sproat aims to bounce back from a rough start against Seth Lugo of the Royals. Lugo’s performance at home has been better, which could factor into the outcome.

Pick: Royals Moneyline -118 and Over 8.5 Runs (Game 2 of Doubleheader) (Greg’s Handicap Royals -152 and Total 9.2)

Atlanta Braves vs. Arizona Diamondbacks

Arizona’s Michael Soroka has shown promise despite a tough year, while Bryce Elder of the Braves struggled last season. This matchup features two teams with differing offensive capabilities.

Pick: Diamondbacks Moneyline -105 (Greg’s Handicap Diamondbacks -118)

Chicago Cubs vs. Cleveland Guardians

The Guardians deploy pitcher Slade Cecconi, who had a shaky 2025 season. Meanwhile, Cubs pitcher Shota Imanaga performed respectably but lacked support from the bullpen in prior outings.